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Chromatograph Mass Spectrometer Product List

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High-precision, rapid, and robust characterization of peptides and proteins.

Comprehensive acquisition of molecular weight, aggregates, amino acid sequence information, etc., using light scattering detectors and LC-MS.

SEC-MALS, which combines size exclusion chromatography and multi-angle static light scattering, is commonly used for the analysis of polymers but is also suitable for molecular weight analysis of low molecular weight (LMW) peptides. Multi-angle light scattering (MALS) detectors such as DAWN and miniDAWN are very useful for online measurement of the molecular weight of peptides under 1,000 daltons. LC-MS allows for detailed characterization analysis, including amino acid sequences and post-translational modifications. By combining LC-MS with SEC-MALS, comprehensive data can be obtained, ranging from detailed analysis to the overall molecular weight and aggregates of peptides. By clicking "Submit," you agree that Waters may use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

  • Light Scattering Photometer
  • High Performance Liquid Chromatograph
  • Mass Spectrometer
  • Chromatograph Mass Spectrometer

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Gas Chromatograph Mass Spectrometer Pursuing High Sensitivity and Stability

Provides the necessary sensitivity and dynamic range for each analysis! A gas chromatograph mass spectrometer with a new detector. It generates high productivity.

Introducing the Clarus SQ 8 GC/MS (Gas Chromatograph Mass Spectrometer). With the adoption of the new "Clarifi" Detector, the Clarus SQ 8 GC/MS pursues further sensitivity and stability, providing the necessary sensitivity and dynamic range for each analysis, resulting in high throughput and productivity. Additionally, it features the new ion source, SMARTsource, which enhances maintenance by further pursuing plug-in capabilities. 【Features】 ◆ Adoption of the new "Clarifi" Detector, achieving high sensitivity and stability ◆ Adoption of a new ion source, improving maintenance with further pursuit of plug-in capabilities ◆ Expansion of analytical methods with the GC sampler TurboMatrix series and Swafer technology *For more details, please refer to the PDF document or feel free to contact us.

  • Other industrial robots
  • Other physicochemical equipment
  • Gas Generator
  • Chromatograph Mass Spectrometer

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High-precision analysis of the complex physicochemical properties of mRNA medicines.

High-precision evaluation of molecular weight, structure, and aggregation using light scattering detectors and LC-MS.

mRNA has been gaining attention as a modality in recent years, but evaluation methods have not yet been established, posing challenges in product development. SEC-MALS (Size Exclusion Chromatography with Multi-Angle Light Scattering detection) serves as a powerful tool for evaluating important biophysical characteristics. By utilizing SEC-MALS, it is possible to measure molecular weight, size, and three-dimensional structure with high precision, obtaining essential information for the development and optimization of mRNA therapeutics. Furthermore, when combined with LC-MS, it enables more comprehensive characterization and biophysical property analysis. The use of LC-MS for the separation and analysis of synthetic nucleic acids is effective, allowing for the simultaneous acquisition of a wide range of information, including purity, impurity content, and sequence confirmation. With the enhancement of dedicated analysis software, anyone can easily perform data analysis, regardless of their experience with LC-MS. By clicking [Submit], you are deemed to have consented to Waters' use and processing of the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

  • Light Scattering Photometer
  • High Performance Liquid Chromatograph
  • Mass Spectrometer
  • Chromatograph Mass Spectrometer

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[Case Study] Residual Pesticide Analysis in Baby Food Using High-Resolution GC-MS

Achieving high selectivity and high sensitivity for accurate quantitative analysis of pesticide residues in food.

The Thermo Scientific Orbitrap Exploris GC mass spectrometer demonstrates excellent performance in pesticide analysis in baby food. This system provides high selectivity and sensitivity with mass resolutions set at 30,000 and 60,000, accurately detecting low concentrations of pesticides from complex sample matrices. The QuEChERS method using citrate buffer was employed for sample preparation. This technical document presents the performance evaluation results of linearity, sensitivity, mass accuracy, and ion ratios for 18 types of pesticides in baby food extracts. All pesticides were detected and identified at the lowest standard concentration of 0.005 mg/kg, with mass accuracy showing high reliability within 1.5 ppm across all concentration levels. 【Features】 ■ Accurate mass measurement at high resolution ■ High selectivity and sensitivity even in complex sample matrices ■ Easy data acquisition and analysis using Thermo Scientific Chromeleon chromatography data system (CDS) software ■ Good linearity with a coefficient of determination of over 0.99 ■ Mass accuracy within 1.5 ppm across all concentration levels

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  • Food Testing/Analysis/Measuring Equipment
  • Analytical Equipment and Devices
  • others
  • Chromatograph Mass Spectrometer

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[Analysis Case] Quantitative Analysis of Acrylamide in Food

Participating in the FAPAS proficiency test ensures the accuracy of analytical values.

In 2002, it was announced that acrylamide, which may have carcinogenic properties, is generated when foods high in carbohydrates are heated at temperatures above 120°C (Figure 1), attracting attention. According to the Ministry of Agriculture, Forestry and Fisheries (MAFF) website, acrylamide is found in many foods, including fried potato snacks, toast, and coffee. At MST, we participate in the proficiency testing FAPAS and confirm that the absolute value of the z-score is 2 or below (satisfactory), allowing us to accurately quantify acrylamide in food using LC/MS/MS.

  • Contract Analysis
  • Chromatograph Mass Spectrometer

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Component Analysis: GC-MS Gas Chromatography Mass Spectrometer

Introducing a new device! We present an analytical method aimed at the qualitative and quantitative analysis of components contained in samples.

We have introduced the "GC-MS Gas Chromatograph Mass Spectrometer" manufactured by Shimadzu Corporation. This is one of the analytical methods aimed at qualitative and quantitative analysis of components contained in samples, used for the qualitative and quantitative analysis of volatile organic compounds such as parts, materials, residual solvents, and additives. It is necessary for the measurement target to be gasified (with a boiling point below 300°C), but it is suitable for component analysis of mixtures due to its higher sensitivity compared to IR and RAMAN, as well as the ability to separate components in the GC section. 【Overview of GC-MS Equipment】 ■ GC-MS Main Unit: GC-2030, GCMS-QP2020 NX ■ Headspace Sampler: HS-20 ■ Pyrolysis Analyzer: Multi-Shot Pyrolyzer Py-3030 ■ Specifications ・Detection Limit: Several ppm (varies depending on the measurement target) ・Headspace: 40–300°C, Sample Size 13mm x 40mm or smaller ・Pyrolysis Analyzer: 50–1050°C (EGA measurement compatible), Sample Size up to 4mm *For more details, please refer to the PDF document or feel free to contact us.

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  • Analytical Equipment and Devices
  • Contract Analysis
  • Chromatograph Mass Spectrometer

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[Case Study] Impurity Analysis of Topiramate by HPLC-CAD

The combination of a single quadrupole mass spectrometer and CAD allows for the identification of known impurities and the prediction of molecular weights and proposed structures of unknown impurities!

This content explains the benefits of combining a Charged Aerosol Detector (CAD) and a Single Quadrupole Mass Spectrometer for impurity analysis of topiramate. The HPLC-UV system is a common analytical method used in many laboratories. By combining CAD and a mass spectrometer with this system, comprehensive impurity detection becomes possible. CAD detects non-volatile and semi-volatile compounds with high sensitivity. The mass spectrometer not only confirms molecular weight but also eliminates the possibility of co-elution by verifying peak purity. Additionally, the in-source Collision-Induced Dissociation (CID) function allows for the confirmation of known impurities and the structural estimation of unknown impurities. 【Features】 ■ Identification of known impurities and molecular weight prediction and structural estimation of unknown impurities ■ High-precision impurity profiling through combination with a Single Quadrupole Mass Spectrometer ■ Peak identification based on m/z and elimination of co-elution possibilities ■ CAD has high sensitivity and a wide dynamic range, accommodating gradient analysis *For more details, please download the PDF or feel free to contact us.

  • Vanquish_Duo_UHPLC.png
  • Thermo ISQ EM with Vanquish_09_2.png
  • Other measurement, recording and measuring instruments
  • Chromatograph Mass Spectrometer

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